Novel Homoleptic Bis(dipyrrinato) Zinc(II) Complexes with Long Lifetimes as Potential Photosensitisers for Photodynamic Therapy
Year: 2019
Type: article
Abstract: The use of photodynamic therapy (PDT) to treat various types of cancer has received increasing attention over the last years. However, the clinically used photosensitisers (PSs) have some limitations that include poor aqueous solubility, hepatotoxicity, photobleaching, aggregation and slow clearance from the body, leading to photosensitivity. To circumvent these drawbacks, the design of new classes of PSs is of high interest. Herein, we present the first example of the use of bis(dipyrrinato)zinc(II) complexes with exceptionally long lifetimes as efficient PDT PSs. Using the heavy atom effect, we could promote the intersystem crossing (ISC) of these complexes to change the character of the excited state from singlet to a triplet state, enabling singlet oxygen (1 O2) generation. To overcome the limitation of quenching effects in water as well as to improve water solubility, the lead compound of this study 3 was encapsulated in a polymer matrix. While having no observed dark toxicity, it showed an impressive phototoxicity upon irradiation at 500 nm in various monolayer cancer cells as well as 3D multicellular tumour spheroids (MCTS).
Source: HAL
Institutions: Chimie ParisTech - PSL, Université Paris Sciences et Lettres
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W4289023716