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Mmp-12在非小细胞肺癌中的研究进展

Year: 2014

Type: article

Abstract: Lung cancer is one of the most common malignant tumors in the world wide. Non-small cell lung cancer (NSCLC) accounts for approximately 80% of lung cancers, its pathogenesis have not been elucidated. Recently, researches have shown that dysregulation and excessive activity of the matrix metalloproteinases (MMPs) has been associated with many pathologies. Some results suggest that the matrix metalloproteinases 12 (MMP-12) participates in the invasion and metastasis of NSCLC. The expression of MMP-12 in non-small cell lung cancer is significantly higher than in adjacent tissues. And studies have shown that the MMP-12 has important prognostic significance in NSCLC. Therefore this article will briefly summarize the research progresses of MMP-12 in NSCLC.

Source: Europe PMC (PubMed Central)

DOI: 10.3779/j.issn.1009-3419.2014.01.05

Authors: Yuan WEN, Li CAI

Institution: Harbin Medical University

Language: English

Topic: Protease and Inhibitor Mechanisms

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4289254159

FWCI:

Cites:

Cited by: 1

Related to: 10