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Intractable pruritic dermatosis of the perineum in a woman with highly unusual pathologic features

Year: 2022

Type: article

Abstract: We present a case of an atypical pruritic dermatosis of the perineum in a woman with highly unusual pathologic features. Initially unresponsive to multiple therapies, the patient responded remarkably quickly to doxepin. However, a gradual loss of efficacy was noted after only 1 month of treatment. Although the histopathologic features of the eruption overlapped somewhat with those of pagetoid dyskeratosis and papular acantholytic dyskeratosis, the absence of either epidermal acantholysis or dyskeratosis and a distinct clinical presentation differentiate this case from other described cases of dermatoses.

Source: JAAD Case Reports

DOI: 10.1016/j.jdcr.2022.07.029