Work

Increased Prevalence of Lassa Fever Virus-Positive Rodents and Diversity of Infected Species Found during Human Lassa Fever Epidemics in Nigeria

Year: 2022

Type: article

Abstract: spp. Our findings also indicate the abundance of LASV-infected small rodents in houses, with probable interspecies transmission through vertical and horizontal coitus routes. Consequently, we suggest that the abundance of different reservoir species for LASV may fuel the epizootic outbreaks of LF in affected human communities. The high prevalence of LASV with the diversity of affected rodents has direct implications for our understanding of the transmission risk, mitigation, and ultimately, the prevention of LF in humans. Optimal tissues for LASV detection in rodents are also presented.

Source: Microbiology Spectrum

DOI: 10.1128/spectrum.00366-22

Authors: Anise N. Happi, Testimony J. Olumade, Olusola A. Ogunsanya, Ayotunde E. Sijuwola, Seto C. Ogunleye, Judith U. Oguzie, Cecilia Nwofoke, Chinedu A. Ugwu, Samuel J. Okoro, Patricia I. Otuh, Louis N. Ngele, Oluwafemi O. Ojo, Ademola Adelabu, Roseline F. Adeleye, Nicholas E. Oyejide, Clinton S. Njaka, Jonathan L. Heeney, Christian T. Happi

Institutions: Redeemer's University, University of Ibadan, Federal Teaching Hospital Abakaliki, Michael Okpara University of Agriculture, Federal Medical Centre, Rufus Giwa Polytechnic, University of Cambridge

Language: English

Topic: Viral Infections and Vectors

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

Funders: Wellcome Trust, UK Research and Innovation, Biotechnology and Biological Sciences Research Council

Awards: G2565828667, One Health and accelerating Vaccines for Ebola and Lassa (OVEL), Lassa outbreak response: early intervention and community response capacity in Ondo, Edo and Ebonyi states, Nigeria, G7789330568

OpenAlex ID: W4289338337

FWCI: 4.522

Cites: 27

Cited by: 50

Related to: 10