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Elevation of neural injury markers in patients with neurologic sequelae after hospitalization for SARS-CoV-2 infection

Year: 2022
Type: article
Study design: Observational Study
Abstract: Patients with SARS-CoV-2 infection (COVID-19) risk developing long-term neurologic symptoms after infection. Here, we identify biomarkers associated with neurologic sequelae one year after hospitalization for SARS-CoV-2 infection. SARS-CoV-2-positive patients were followed using post-SARS-CoV-2 online questionnaires and virtual visits. Hospitalized adults from the pre-SARS-CoV-2 era served as historical controls. 40% of hospitalized patients develop neurological sequelae in the year after recovery from acute COVID-19 infection. Age, disease severity, and COVID-19 infection itself was associated with additional risk for neurological sequelae in our cohorts. Glial fibrillary astrocytic protein (GFAP) and neurofilament light chain (NF-L) were significantly elevated in SARS-CoV-2 infection. After adjusting for age, sex, and disease severity, GFAP and NF-L remained significantly associated with longer term neurological symptoms in patients with SARS-CoV-2 infection. GFAP and NF-L warrant exploration as biomarkers for long-term neurologic complications after SARS-CoV-2 infection.
Source: iScience
DOI: 10.1016/j.isci.2022.104833
Authors: Michail Spanos, Sigal Shachar, Thadryan Sweeney, H. Immo Lehmann, Priyanka Gokulnath, Guoping Li, George B. Sigal, Rajini Nagaraj, Pradeepthi Bathala, Farhan Rana, Ravi V. Shah, David A. Routenberg, Saumya Das
Language: English
Subfield: Neurology
Field: Medicine
Open Access status: gold
Estimated APC paid: $3,000
Awards: Enabling isolation and characterization of single extracellular vesicles and their molecular contents using multi-marker surface signatures, Surface Signatures of Neuronal and Glial Extracellular Vesicles, Surface Signatures of Neuronal and Glial Extracellular Vesicles, Molecular dissection and imaging of extracellular vesicles to define their origin and targets, Enabling isolation and characterization of single extracellular vesicles and their molecular contents using multi-marker surface signatures, Functional role and therapeutic targeting of exosomes and extracellular RNA biomarkers in heart failure
OpenAlex ID: W4289339193
FWCI: 2.501
Cites: 62
Cited by: 21
Related to: 10