Work

Aspergillus fumigatus FhdA Transcription Factor Is Important for Mitochondrial Activity and Codon Usage Regulation during the Caspofungin Paradoxical Effect

Year: 2022

Type: article

Abstract: Aspergillus fumigatus is the main etiological agent of aspergillosis. The antifungal drug caspofungin (CSP) can be used against A. fumigatus, and CSP tolerance is observed. We have previously shown that the transcription factor FhdA is important for mitochondrial activity. Here, we show that FhdA regulates genes transcribed by RNA polymerase II and III. FhdA influences the expression of tRNAs that are important for mitochondrial function upon CSP. Our results show a completely novel mechanism that is impacted by CSP.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00701-22

Authors: Ana Cristina Colabardini, Norman Van Rhijn, Abigail L. LaBella, Clara Valero, Fang Wang, Lauren Dineen, Michael J. Bromley, Antonis Rokas, Gustavo H. Goldman

Institutions: Universidade de São Paulo, University of Manchester, Vanderbilt University, Shenzhen University, Shenzhen Second People's Hospital

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Wellcome Trust, Fundação de Amparo à Pesquisa do Estado de São Paulo, Ministério da Ciência, Tecnologia e Inovação, Conselho Nacional de Desenvolvimento Científico e Tecnológico, National Institutes of Health, National Institute of Allergy and Infectious Diseases

Awards: The Aspergillus fumigatus gene and non-coding RNA knockout library, G2094929424, G261077543, G339059223, Understanding and mitigating the impact of emerging antifungal resistance, G3586123364, G4390630094, G4639098800, G5600336426, The Aspergillus fumigatus gene and non-coding RNA knockout library, The influence of mitogen activated protein kinases (MAPK) on the expression of genetic determinants important for Aspergillus fumigatus virulence, G7161932920, G7248186603, Understanding and mitigating the impact of emerging antifungal resistance, G806931074, G8082343172, G8275295818, G8844515812, Deciphering the phenotypic and genomic traits that underlie the evolution of pathogenicity differences among Aspergillus fumigatus and its close relatives

OpenAlex ID: W4289522378

FWCI: 0.227

Cites: 10

Cited by: 2

Related to: 10