Protein Design: From the Aspect of Water Solubility and Stability
Year: 2022
Type: review
Abstract: transmembrane protein design. Traditional strategies to enhance protein solubility and structural stability are introduced. The designs of stable protein complexes and high-order assemblies are covered. Computational methodologies behind these endeavors, including structure prediction programs, machine learning algorithms, and specialty software dedicated to the evaluation of protein solubility and aggregation, are discussed. The findings and opportunities for Cryo-EM are presented. This review provides an overview of significant progress and prospects in accurate protein design for solubility and stability.
Source: Chemical Reviews
Authors: Rui Qing, Shilei Hao, Eva Smorodina, David Jin, Arthur Zalevsky, Shuguang Zhang
Institutions: Shanghai Jiao Tong University, Koch Institute for Integrative Cancer Research At MIT, State Key Laboratory of Microbial Metabolism, MIT Media Lab, Massachusetts Institute of Technology, Chongqing University, Oslo University Hospital, University of Oslo, Institute of Bioorganic Chemistry
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $5,000
OpenAlex ID: W4289653737