Work

Designing Microbial Cell Factories for the Production of Chemicals

Year: 2022

Type: review

Abstract: pathways (as nonnative-created pathways) are discussed in this Perspective. We highlight key approaches and successful case studies that exemplify these concepts. Once these pathways are designed and constructed in the microbial cell factory, systems metabolic engineering strategies can be used to improve the performance of the strain to meet industrial production standards. In the second part of the Perspective, current trends in design tools and strategies for systems metabolic engineering are discussed with an eye toward the future. Finally, we survey current and future challenges that need to be addressed to advance microbial cell factories for the sustainable production of chemicals.

Source: JACS Au

DOI: 10.1021/jacsau.2c00344

Authors: Jae Sung Cho, Gi Bae Kim, Hyunmin Eun, Cheon Woo Moon, Sang Yup Lee

Institution: Korea Advanced Institute of Science and Technology

Language: English

Topic: Microbial Metabolic Engineering and Bioproduction

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $5,000

Funders: Hanwha Solutions, National Research Foundation of Korea