Recapitulated Crosstalk between Cerebral Metastatic Lung Cancer Cells and Brain Perivascular Tumor Microenvironment in a Microfluidic Co‐Culture Chip (Adv. Sci. 22/2022)
Year: 2022
Type: article
Abstract: Microfluidic Co-Culture Chip In article number 2201785 by Hye Won Lee, Seok Chung, and co-workers, development of a microfluidic triculture chip to simulate interactions between brain metastatic tumor cells and the microenvironment of the brain tumor is described. The microfluidic chip allows for the cultivation of patient-derived cells in complex components of reconstituted brain, as well as the spatial collection of conditioned media and cells for a variety of biological analyses. This innovative platform allows the screening of drugs that target the intercellular communication between metastatic cancer cells and microenvironmental components at the metastatic site.
Source: Advanced Science
Authors: Hyunho Kim, Jason K. Sa, Jaehoon Kim, Hee Jin Cho, Hyun Jeong Oh, Dong‐Hee Choi, Seok‐Hyeon Kang, Da Eun Jeong, Do‐Hyun Nam, Hakho Lee, Hye Won Lee, Seok Chung
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $5,200
OpenAlex ID: W4289861488