Work

Identification and Implications of HIV-1 CRF01_AE Subtype in Hawai'i.

Year: 2022

Type: article

Abstract: Human Immunodeficiency Virus has a high propensity for genetic variation, demonstrated by its complex phylogeny and multiplicity of subtypes. Subtype B is predominant in North America as well as in Hawai'i while CRF01_AE is found in over 50% of cases in the Philippines and Southeast Asia. In a small collaborative study between the Hawai'i Center for AIDS and Philippines General Hospital, molecular phylogenetic subtyping was conducted on HIV+ participants. Two of 15 (13%) participants from the Hawai'i cohort and 12 of 21 (57%) participants from the Philippines cohort were identified as having CRF01_AE subtype of HIV-1, with remaining participants identified as subtype B. While one individual in Hawai'i with CRF01_AE had emigrated from the Philippines, the other participant from Hawai'i with CRF01_AE subtype was a local individual, born and raised in Hawai'i. The authors report that HIV subtype diversity may be increased in Hawai'i and discuss its potential clinical and public health implications.

Source: PubMed Central

Authors: Logan S Dean, Ivo N SahBandar, Cecilia M Shikuma

Institutions: University of Hawaiʻi at Mānoa, Weill Cornell Medicine

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of General Medical Sciences, National Institute on Minority Health and Health Disparities

Awards: Ola HAWAII, Center for Pacific Innovations, Knowledge, and Opportunities (PIKO), Transdisciplinary Health Disparities Research Training for Native Hawaiians and Pacific Students