Differences in clinical presentation, severity, and treatment of COVID-19 among individuals with Down syndrome from India and high-income countries: Data from the Trisomy 21 Research Society survey
Year: 2022
Type: article
Study design: Observational Study
Abstract: Background: People with Down syndrome (DS) are one of the highest risk groups for mortality associated with COVID-19, but outcomes may differ across countries due to different co-morbidity profiles, exposures, and societal practices, which could have implications for disease management. This study is designed to identify differences in clinical presentation, severity, and treatment of COVID-19 between India and several high-income countries (HICs). Methods: We used data from an international survey to examine the differences in disease manifestation and management for COVID-19 patients with DS from India vs HIC. De-identified survey data collected from April 2020 to August 2021 were analysed. Results: COVID-19 patients with DS from India were on average nine years younger than those from HICs. Comorbidities associated with a higher risk for severe COVID-19 were more frequent among the patients from India than from HICs. Hospitalizations were more frequent among patients from India as were COVID-19-related medical complications. Treatment strategies differed between India and HICs, with more frequent use of antibiotics in India. The average severity score of 3.31 was recorded for Indian DS in contrast to 2.3 for European and 2.04 for US cases. Conclusions: Presentation and outcomes of COVID-19 among individuals with DS were more severe for patients from India than for those from HIC. Global efforts should especially target vaccination campaigns and other risk-reducing interventions for individuals with DS from low-income countries.
Source: Journal of Global Health
Authors: Halder Pinku, Anke Hüls, Patrick T Feany, Nicole Baumer, Mara Dierssen, Stefania Bargagna, Alberto CS Costa, Brian A Chicoine, Anne-Sophie Rebillat, Giuseppina Sgandurra, Diletta Valentini, R Tilman Rohrer, Johannes Levin, Monica Lakhanpaul, Angelo Carfì, Stephanie L Sherman, Andre Strydom, Sujay Ghosh
Institutions: University of Calcutta, Emory University, Boston Children's Hospital, Harvard University, Universitat Pompeu Fabra, Centre for Biomedical Network Research on Rare Diseases, Barcelona Institute of Science and Technology, Centre for Genomic Regulation, Fondazione Stella Maris, Case Western Reserve University, Fondation Jérôme-Lejeune, Bambino Gesù Children's Hospital, Istituti di Ricovero e Cura a Carattere Scientifico, Universitätsklinikum des Saarlandes, German Center for Neurodegenerative Diseases, Munich Cluster for Systems Neurology, Ludwig-Maximilians-Universität München, Whittington Health NHS Trust, University College London, Agostino Gemelli University Polyclinic, King's College London
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,200
Funders: National Down Syndrome Society, Infectious Diseases Society of America, Emory University, Global Down Syndrome Foundation, Ministerio de Ciencia, Innovación y Universidades, North Dakota Soybean Council, European Commission, Department of Science and Technology, Ministry of Science and Technology, India, National Institutes of Health, Medical Research Council, Departament d'Universitats, Recerca i Societat de la Informació, National Institute on Aging, National Institute of Environmental Health Sciences, National Institute of Child Health and Human Development, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1179831539, The Role of Inflammation and NGF Dysfunction in the Evolution of AlzheimerDisease Pathology in Down syndrome, G2913662408, G3006186625, G3446024718, G4377920894, Gene overdosage and comorbidities during the early lifetime in Down Syndrome, G5514976981, G6848103159, Tau pathology in Down syndrome and Alzheimer's, Institute for Clinical and Translational Research, Biological Correlates of Alzheimer in Down Syndrome., Boston Children's Hospital/HMS Intellectual and Developmental Disabilities Research Center, HERCULES: Exposome Research Center
OpenAlex ID: W4290072845