The ebb and flow of cardiac lymphatics: a tidal wave of new discoveries
Year: 2022
Type: review
Abstract: The heart is imbued with a vast lymphatic network that is responsible for fluid homeostasis and immune cell trafficking. Disturbances in the forces that regulate microvascular fluid movement can result in myocardial edema, which has profibrotic and proinflammatory consequences and contributes to cardiovascular dysfunction. This review explores the complex relationship between cardiac lymphatics, myocardial edema, and cardiac disease. It covers the revised paradigm of microvascular forces and fluid movement around the capillary as well as the arsenal of preclinical tools and animal models used to model myocardial edema and cardiac disease. Clinical studies of myocardial edema and their prognostic significance are examined in parallel to the recent elegant animal studies discerning the pathophysiological role and therapeutic potential of cardiac lymphatics in different cardiovascular disease models. This review highlights the outstanding questions of interest to both basic scientists and clinicians regarding the roles of cardiac lymphatics in health and disease.
Source: Physiological Reviews
Institution: University of North Carolina at Chapel Hill
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: GPCR-mediated pathways for regulation of intestinal lymphatic function, G1548839465, G3710101674, Cardiac Lymphatics in the Resolution of Myocardial Edema, G6936564476, Elucidating the VE-cadherin protein network governing lymphatic function and permeability, G8627865084, Pre-doctoral Training Program in Integrative Vascular Biology
OpenAlex ID: W4290960084