Association of time of breakfast and nighttime fasting duration with breast cancer risk in the multicase-control study in Spain
Year: 2022
Type: article
Study design: Observational Study
Abstract: Circadian nutritional behaviors, defined by the daily eating/fasting cycle, have been linked with breast cancer. This study aimed to further disentangle the association of nighttime fasting duration and time of breakfast with breast cancer risk. We analyzed data from 1,181 breast cancer cases and 1,326 population controls from the Spanish multicase-control study (MCC-Spain), 2008–2013. We collected circadian nutritional behaviors at mid-age via a telephonic interview. We applied logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CIs) for the association of nighttime fasting duration and time of breakfast with breast cancer risk in all women and stratified by menopausal status. Models were adjusted for age, center, education, family history of breast cancer, age at menarche, number of children, breastfeeding, age at first child, body mass index (BMI), contraceptive use, and hormonal replacement therapy (HRT). A later time of breakfast was associated with a non-significant increased risk of breast cancer (OR = 1.05, 95% CI: 0.95–1.16, per hour increase). This association was stronger among premenopausal women, among whom each hour later, the time of breakfast was associated with an 18% increase in breast cancer risk (OR = 1.18, 95% CI: 1.01–1.40). The association was not observed in postmenopausal women. We did not observe an association between nighttime fasting duration and breast cancer risk after adjusting for the time of breakfast. In this study, late breakfast was associated with increased breast cancer risk, especially among premenopausal women, compared with early breakfast. Aside from nutritional quality, circadian nutritional behaviors should be further studied in relation to cancer.
Source: Frontiers in Nutrition
Authors: Anna Palomar-Cros, Barbara N. Harding, Ana Espinosa, Kyriaki Papantoniou, Beatriz Pérez-Gómez, Kurt Straif, Eva Ardanaz, Tania Fernández Villa, Pilar Amiano, Inés Gómez-Acebo, Victor Moreno, Juan Alguacil, Guillermo Fernández-Tardón, Ana Molina-Barceló, Rafael Marcos-Gragera, Nuria Aragonés, Gemma Castaño-Vinyals, Marcela Guevara, Alba Marcos Delgado, Marina Pollán, Dora Romaguera, Manolis Kogevinas
Institutions: Universitat Pompeu Fabra, Barcelona Institute for Global Health, Instituto de Salud Carlos III, Hospital Del Mar, Municipal Institute for Medical Research, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Hospital del Mar Research Institute, Medical University of Vienna, Centro Nacional de Epidemiología, Boston College, Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, Universidad de León, Basque Government, Biogipuzkoa Health Research Institute, Universidad de Cantabria, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Universitat de Barcelona, Universidad de Huelva, Universidad de Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, Generalitat de Catalunya, Departament de Salut, Institut d'Investigació Biomèdica de Girona, Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Centro de Investigación Biomédica en Red, Health Research Institute of the Balearic Islands
Language: English
Topic: Dietary Effects on Health
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,490
Funders: “la Caixa” Foundation, Centres de Recerca de Catalunya, European Commission, Generalitat de Catalunya, Ministerio de Economía y Competitividad, Generalitat Valenciana, Ministerio de Ciencia e Innovación, Universidad de Oviedo, Consejería de Salud y Familias, Junta de Andalucía, Junta de Andalucía, Junta de Castilla y León, Fundación Marqués de Valdecilla, Agència de Gestió d'Ajuts Universitaris i de Recerca, Instituto de Salud Carlos III
Awards: G1173657325, G1203044189, G1274129560, G1317564010, G1343860231, G1418927621, G1492351230, G1562456565, G1563087297, G1656120899, G1677669578, G178315305, G1900157527, G2045172656, G2092426522, G2117726266, Salud urbana desde el enfoque de exposoma: evaluación de la exposición ambiental individualizada en un estudio de cohortes de población de adultos (GCAT), G2247562131, G2377181310, G2553834064, G2620658983, G2739777946, G2957026379, G3057128404, G3405515844, G3423777635, G3559709381, G3583461342, G3635063837, G3646853989, G3771020718, G3807906117, G43203158, Identificación de marcadores de susceptibilidad genética útiles para el diseño de estrategias personalizadas de cribado, G4502495630, G4505522013, G4561499809, G4600474357, G4623508005, G4628349315, G4744727092, G5159276886, G521056402, G5429904378, G556022927, G5578457147, G5675886668, G5842727755, G5850051156, G5881411584, G5890873539, G5893827543, G589846866, G6140283827, G6260981759, G6328075693, G6386293926, G6425491107, G6508629688, G6600723041, G687257720, G702470302, G7029154051, G7517354179, G7558450789, G7688125627, G7694266246, G7868651054, G7932779895, G8214743223, G8619603317, G8630196938, G8835261403, Perfil molecular del envejecimiento en la patogénesis y pronóstico de la leucemia linfática crónica
OpenAlex ID: W4291018616