Year: 2022
Type: article
Abstract: The study by Chen et al also has limitations: first and foremost, the models adopted by the researchers may be too simplistic in terms of rebuilding a niche in vitro or the models may be misleading by analyzing cells that have already been exposed to a targeted drug.Additional work is needed to determine the actual importance of these metabolic circuits.The second important limitation is that the authors have not segregated CLL cells according to their molecular lesions: this may be important for understanding CLL progression and eventual transformation into Richter syndrome.It will be interesting to know how specific genetic lesions directly impact the metabolic pathways of these cells.What remains a fascinating mystery is why CLL cells so rapidly leave the LNs instead of remaining in a nutrient-rich, favorable environment.What is that telling us about the cell of origin?Conflict-of-interest disclosure: The author declares no competing financial interests.
Source: Blood
Authors: Helong Zhao, Michael W. Deininger
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4291020253