Impact of Seasonal Coronavirus Antibodies on Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Responses in Solid Organ Transplant Recipients
Year: 2022
Type: article
Study design: Observational Study
Abstract: Antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination are reduced in solid organ transplant recipients (SOTRs). We report that increased levels of preexisting antibodies to seasonal coronaviruses are associated with decreased antibody response to SARS-CoV-2 vaccination in SOTRs, supporting that antigenic imprinting modulates vaccine responses in SOTRs.
Source: Clinical Infectious Diseases
DOI: 10.1093/cid/ciac652
Authors: Andrew H Karaba, Weiqiang Zhou, Shuai Li, Tihitina Y Aytenfisu, Trevor S Johnston, Olivia Akinde, Yolanda Eby, Aura T Abedon, Jennifer L Alejo, Caroline X Qin, Elizabeth A Thompson, Jacqueline M Garonzik-Wang, Joel N Blankson, Andrea L Cox, Justin R Bailey, Sabra L Klein, Andrew Pekosz, Dorry L Segev, Aaron A R Tobian, William A Werbel
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Johns Hopkins Excellence in Pathogenesis and Immunity Center for SARS-CoV-2 (JH-EPICS), Patient Oriented Research in Solid Organ Transplantation, G3669211853, G5161451462, Expanding HOPE Liver Transplantation: Understanding Opportunistic Infection and Cancer Risk, Clinical and Laboratory Research Training for Gastrointestinal Surgeons, Modulation of Herpes Simplex Virus Pathogenesis by Leucine Rich Repeat Kinase 2, The Landscape of Serious Infections following Kidney Transplantation in People Living with HIV
OpenAlex ID: W4291634474