Arsenic exposure increases susceptibility to Ptpn11-induced malignancy in mouse embryonic fibroblasts through mitochondrial hypermetabolism.
Year: 2022
Type: article
Abstract: OBJECTIVE: gain-of-function mutation on tumorigenesis. METHODS: . To detect mitochondrial oxidative phosphorylation (OXPHOS), we used Seahorse real-time cell metabolic analysis as well as adenosine triphosphate (ATP) and ROS production assays. Lastly, we examined mTOR signaling pathway changes by western blotting. RESULTS: mutation was prevented by mTOR pathway inhibition via rapamycin. CONCLUSION: -associated cancers.
Source: PubMed
Institution: Anhui Medical University
Language: English
Subfield: Environmental Chemistry
Field: Environmental Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W4291708451