Work

Structural Insights into Function of Ionotropic Glutamate Receptors

Year: 2022

Type: article

Abstract: Ionotropic glutamate receptors (iGluRs) mediate fast excitatory neurotransmission. They are implicated in nervous system development and function, while their dysfunction is associated with neurological and psychiatric disorders. In this review, we describe recent progress in structural studies of iGluRs and how crystal and cryo-EM structures helped determining the principles of iGluR architecture and assembly, and the mechanisms of activation, desensitization and regulation by auxiliary subunits, positive and negative allosteric modulators, and ion channel blockers. The new structural insights facilitate better understanding of iGluR physiological and pathophysiological roles in functioning of the central nervous system and provide valuable information for structure-based drug design.

Source: Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology

DOI: 10.1134/s1990747822040043

Authors: M. V. Yelshanskaya, A. I. Sobolevsky

Institution: Columbia University

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funders: National Cancer Institute, National Institute of Neurological Disorders and Stroke

Awards: Structure and Function of AMPA subtype ionotropic glutamate receptors, Single-Particle Cryo-EM Characterization of AMPA Receptor Functional States, Structure and function of Transient Receptor Potential Channels