NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression
Year: 2025
Type: article
Source: Immunity
Authors: Róisín M. McManus, Max P. Komes, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Juan Ramón Perea, Johannes C.M. Schlachetzki, David S. Bouvier, Michelle-Amirah Khalil, Mario A. Lauterbach, Lea Heinemann, Titus Schlüter, Mehran Shaban Pour, Marta Lovotti, Rainer Stahl, Fraser Duthie, Juan F. Rodríguez-Alcázar, Susanne V. Schmidt, Jasper Spitzer, Peri Noori, Alberto Maillo, Andreas Boettcher, Brian Herron, John McConville, David Gomez-Cabrero, Jesper Tegnér, Christopher K. Glass, Karsten Hiller, Eicke Latz, Michael T. Heneka
Institutions: University Hospital Bonn, German Center for Neurodegenerative Diseases, Centro de Biología Molecular Severo Ochoa, University of California San Diego, University of Luxembourg, Laboratoire National de Santé, Luxembourg Centre for Systems Biomedicine, Technische Universität Braunschweig, Karolinska Institutet, Universidad Pública de Navarra (UPNA), Navarre Institute of Health Research, Navarrabiomed, Novartis (Switzerland), Novartis Institutes for BioMedical Research, Belfast Health and Social Care Trust, Royal Victoria Hospital, Ulster Hospital, King Abdullah University of Science and Technology, Science for Life Laboratory, University of Massachusetts Chan Medical School, Norwegian University of Science and Technology, German Rheumatism Research Centre
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Funders: Alzheimer's Association, BrightFocus Foundation, JPB Foundation, Alzheimer Forschung Initiative, EU Joint Programme – Neurodegenerative Disease Research, CAPS Research, Doerenkamp-Zbinden Stiftung, European Commission, Helmholtz-Gemeinschaft, Deutsche Forschungsgemeinschaft, Volkswagen Foundation, Deutsches Zentrum für Neurodegenerative Erkrankungen, Helmholtz Association, National Institutes of Health, National Institute on Aging, National Institute of Neurological Disorders and Stroke
Awards: G1607712647, G1711854237, SFB 1454: Metaflammation und Zelluläre Programmierung, A high-dimensional approach for unwinding immune-metabolic causes of cardiovascular disease-depression multimorbidities, Role of inflammasomes in Alzheimer's Disease, S14 Sphingomyelin – The Link Between Obesity and Alzheimer’s Disease, Genomic integrity in Alzheimer's disease, EXC 2151: ImmunoSensation2 the immune sensory system, Mechanisms controlling human microglia gene expression
OpenAlex ID: W4407086665