Trafficking of NMDA receptors is essential for hippocampal synaptic plasticity and memory consolidation
Year: 2022
Type: article
Abstract: NMDA receptor (NMDAR) plays a vital role in brain development and normal physiological functions. Surface trafficking of NMDAR contributes to the modulation of synaptic functions and information processing. However, it remains unclear whether NMDAR trafficking is independent of long-term potentiation (LTP) and whether it regulates behavior. Here, we report that LTP of AMPAR and NMDAR can occur concurrently and that NMDAR trafficking can regulate AMPAR trafficking and AMPAR-mediated LTP. By contrast, AMPAR trafficking does not impact NMDAR-mediated LTP. Using SAP97-interfering peptide and SAP97 knockin (KI) rat, we show that the effect is mediated by GluN2A-subunit-containing NMDARs. At the behavior level, impaired NMDAR trafficking results in deficits in consolidation, but not acquisition, of fear memory. Collectively, our results suggest the essential role of NMDAR trafficking in LTP and memory consolidation.
Source: Cell Reports
Authors: Xin Yang, Ru Gong, Linwei Qin, Yifei Bao, Yi Fu, Shan Gao, Hui Yang, Jinfei Ni, Ti-Fei Yuan, Wei Lu
Institutions: Southeast University, Shanghai Medical College of Fudan University, Fudan University, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Frontiers Center for Brain Science of the Ministry of Education, Shanghai Jiao Tong University, Shanghai Mental Health Center, Shanghai Key Laboratory of Psychotic Disorders, Nantong University, Nanjing Medical University
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,200
OpenAlex ID: W4291991159