Early treatment regimens achieve sustained virologic remission in infant macaques infected with SIV at birth
Year: 2022
Type: article
Abstract: Early antiretroviral therapy (ART) in HIV-infected infants generally fails to achieve a sustained state of ART-free virologic remission, even after years of treatment. Our studies show that viral reservoir seeding is different in neonatal macaques intravenously exposed to SIV at birth, in contrast to adults. Furthermore, one month of ART including an integrase inhibitor, initiated at day 3, but not day 4 or 5 post infection, efficiently and rapidly suppresses viremia to undetectable levels. Intervention initiated at day 3 post infection and continued for 9 months achieves a sustained virologic remission in 4 of 5 infants. Collectively, an early intervention strategy within a key timeframe and regimen may result in viral remission or successful post-exposure prophylaxis for neonatal SIV infection, which may be clinically relevant for optimizing treatment strategies for HIV-infected or exposed infants.
Source: Nature Communications
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,890
Funders: Gilead Sciences, ViiV Healthcare, National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Institute of Dental and Craniofacial Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Office of Research Infrastructure Programs, National Institutes of Health
Awards: Early Immune Development and Function in Neonates Exposed to Maternal HIV Infection, Novel strategies for eliminating HIV reservoirs in lymphoid tissues, G3458902986, G4495922382, Impact of tuberculosis on the development and function of the immune system in SIV-infected infants, G9000037928, G9000069411, G9000195158, G9000243865
OpenAlex ID: W4292004274