Work

Evolution and Transmission of Cefiderocol-Resistant Acinetobacter baumannii During an Outbreak in the Burn Intensive Care Unit

Year: 2022

Type: article

Study design: Observational Study

Abstract: We report on 11 critically ill burn patients treated with cefiderocol for carbapenem-resistant Acinetobacter baumannii infections. Clinical success was achieved in 36% and complicated by treatment-emergent resistance and interpatient transmission of cefiderocol-resistant A. baumannii. Resistant isolates harbored disrupted pirA and piuA genes that were not disrupted among susceptible isolates.

Source: Clinical Infectious Diseases

DOI: 10.1093/cid/ciac647

Authors: Steven M Smoke, Alison Brophy, Samuel Reveron, Alina Iovleva, Ellen G Kline, Michael Marano, Lincoln P Miller, Ryan K Shields

Institutions: Saint Barnabas Medical Center, University of Pittsburgh

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences

Awards: Use of site-specific pharmacokinetics to optimize antibiotic combinations and prevent the emergence of resistance against CRE, Characterization and suppression of resistance to new CRE agents, Institutional Career Development Core

OpenAlex ID: W4292171937

FWCI: 3.44

Cites: 18

Cited by: 54

Related to: 10