Work

Editorial: Contemporary challenges in diagnosis and treatment of predominantly antibody deficiency

Year: 2022

Type: editorial

Abstract: Editorial on the Research Topic Contemporary challenges in diagnosis and treatment of predominantly antibody deficiencyPrimary immunodeficiencies (PID) otherwise referred to as Inborn Errors of Immunity (IEI) are rare inherited diseases of the immune system.According to the International Union of Immunological Societies (IUIS) classification, predominantly antibody deficiency (PAD) is the most common PID, characterised by low serum immunoglobulin levels, poor vaccination responses and a high incidence of infectious and non-infectious complications including cancer.In adults, IgA deficiency (IgAD) and Common Variable Immunodeficiency Disorders (CVID) comprise the majority of these conditions.Diverse clinical, immunological, and genetic phenotypes in PAD result in diagnostic delays and poor access to targeted treatments, accounting for the early mortality and high morbidity of this population.The current series of fourteen articles on Contemporary Challenges in Diagnosis and Treatment of PAD explores aspects of the diagnosis and treatment of of this group of conditions.Here, the editors of this section summarise the main findings of the articles in this series.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2022.959720

Authors: Rohan Ameratunga, Hassan Abolhassani, Paul J. Maglione, Emily S. J. Edwards