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Ptchd1 mediates opioid tolerance via cholesterol-dependent effects on μ-opioid receptor trafficking

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Year: 2022
Type: article
Source: Nature Neuroscience
DOI: 10.1038/s41593-022-01135-0
Authors: Nycole Maza, Dandan Wang, Cody Kowalski, Hannah M. Stoveken, Maria Dao, Omar K. Sial, Andrew C. Giles, Brock Grill, Kirill A. Martemyanov
Institutions: Seattle Children's Research Institute, University of Washington, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology
Language: English

Topic: Receptor Mechanisms and Signaling
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, National Eye Institute, National Institute of General Medical Sciences
Awards: G124575536, G1920171928, G3182202053, G3357364380, G3701616646, Investigating New Roles for Orphan GPCRs in Opioid Actions, G4192132923, G4256445460, G4760227921, G5761540164, G6069442866, Molecular Analysis of Disease Pathways, G6995340370, Regulation of Striatal GPCR Signaling, G8680300784, Molecular genetic mechanisms of opioid receptor signaling, G9000086281, G9000180596, G9000336560, Molecular Basis of Photoreceptor Wiring, G915003425
OpenAlex ID: W4292249709
FWCI: 1.243
Cites: 61
Cited by: 24
Related to: 10
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