Year: 2022
Type: article
Abstract: Coccidioides immitis and posadasii are closely related fungal species that cause coccidioidomycosis. These dimorphic organisms cause disease in immunocompetent as well as immunocompromised individuals and as much as 40% of the population is infected in the endemic area. Although most infections resolve spontaneously, the infection can be prolonged and, in some instances, fatal. Coccidioides has been studied for more than 100 years and many aspects of the organism and the disease it causes have been investigated. There are over 500 manuscripts concerning Coccidioides (excluding clinical articles) referenced in PubMed over the past 50 years, so there is a large body of evidence to review. We reviewed the most accurate and informative basic research studies of these fungi including some seminal older studies as well as an extensive review of current research. This is an attempt to gather the most important basic research studies about this fungus into one publication. To focus this review, we will discuss the mycology of the organism exclusively rather than the studies of the host response or clinical studies. We hope that this review will be a useful resource to those interested in Coccidioides and coccidioidomycosis.
Source: Journal of Fungi
DOI: 10.3390/jof8080859
Institutions: University of California San Diego, California Institute for Medical Research, Stanford Medicine, Stanford University, The University of Texas at San Antonio, J. Craig Venter Institute, University of California, Berkeley, University of Arizona, Washington State University, University of California, Los Angeles, Kern Medical Center, California State University, Bakersfield, VA San Diego Healthcare System
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,094
Awards: G1365317380, G167497083, Exploiting Natural Genetic and Organismic Variation to Identify the DNA Motifs Regulating Transcription, G1927345445, G2319185615, G2585273727, G2776625887, G3026780227, G4724336502, G4798626164, G5051069534, G572867437, G6766732718, G685346902, G7028498821, G728285920, G8859371417, G9000038344, G9000063229, G9000285233, Host Immunogenetics and Fungal Virulence Mechanisms in Coccidioidomycosis
OpenAlex ID: W4292295277