Synthesis of mono-fluoromethyl 6,5-heteroaromatic bicycles using 1,3-difluoroacetone as a cyclising reagent
Year: 2022
Type: preprint
Abstract: The development of facile, wide scope synthetic methodologies providing access to fluorinated motifs is important in medic-inal chemistry; for our purposes, we are interested in developing fluorine-tagged compounds to investigate their utility in Huntington’s disease. Here, we describe a novel, operationally simple and mild procedure for the synthesis of mono-fluoromethyl 6,5-heteroaromatic bicycles using 1,3-difluoroacetone (DFA). The scope of the reaction was investigated, and 27 examples synthesized with yields up to 96%.
Source: ChemRxiv
Authors: Longbin Liu, Brett Cosgrove, Cole Clissold, Karine Malagu, Mark Chambers, Celia Dominguez
Institutions: CHDI Foundation, Charles River Laboratories (United Kingdom)
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
Funder: CHDI Foundation
OpenAlex ID: W4292373690