Work

Impact of Innate Immunity, Endothelial Damage, and Metabolic Biomarkers on COVID-19 Severity and Mortality

Year: 2022

Type: article

Abstract: In this study, abnormal levels of myeloid activation, endothelial damage, and innate immune markers were associated with severe coronavirus disease 2019 (COVID-19), while higher levels of metabolic biomarkers (irisin, leptin) demonstrated a protective effect. These data support a model for COVID-19 immunopathogenesis linking robust inflammation and endothelial damage in metabolically predisposed individuals.

Source: Open Forum Infectious Diseases

DOI: 10.1093/ofid/ofac427

Authors: Joseph M Rocco, Paola Laghetti, Mariantonietta Di Stefano, Irini Sereti, Ana Ortega-Villa, Jing Wang, Adam Rupert, Maria Chironna, Peiying Ye, Xiangdong Liu, Megan V Anderson, Peter B Burbelo, Jose Ramon Fiore, Annalisa Saracino, Andrea Lisco

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari, University of Bari Aldo Moro, University of Foggia, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc. (United States), National Institute of Dental and Craniofacial Research

Language: English

Topic: COVID-19 Clinical Research Studies

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,676

Funders: U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institute of Dental and Craniofacial Research

Awards: G1556807729, G4258602497, G4354040965, G5091436655, G5560381666, G585697667, G7302055825

OpenAlex ID: W4292440787

FWCI: 0.611

Cites: 30

Cited by: 6

Related to: 10