Year: 2022
Type: review
Abstract: distributions of anticancer nano-drug delivery systems. However, problems still exist in the delicate balance between improved anticancer efficacy and reduced toxicity to normal tissues, and opportunities arise along with the development of smart stimuli-responsive delivery strategies. By on-demand responsiveness towards exogenous or endogenous stimulus, these smart delivery systems hold promise for advanced tumor-specificity as well as controllable release behavior in a spatial-temporal manner. Meanwhile, the blossom of nanotechnology, material sciences, and biomedical sciences has shed light on the diverse modern drug delivery systems with smart characteristics, versatile functions, and modification possibilities. This review summarizes the current progress in various strategies for smart drug delivery systems against malignancies and introduces the representative endogenous and exogenous stimuli-responsive smart delivery systems. It may provide references for researchers in the fields of drug delivery, biomaterials, and nanotechnology.
Source: Acta Pharmaceutica Sinica B
Institutions: Southwest University, Peking University, State Key Laboratory of Natural and Biomimetic Drugs, Soochow University, Chinese Academy of Sciences, Shanghai Institute of Materia Medica, Shenyang Pharmaceutical University, Central South University, National Center for Nanoscience and Technology, Jilin University
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid:
Awards: G6081110474, G6851365249, G721564894
OpenAlex ID: W4292641171