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Diagnostic MALDI-TOF MS can differentiate between high and low toxic Staphylococcus aureus bacteraemia isolates as a predictor of patient outcome

Year: 2022

Type: article

Abstract: bacteraemia (SAB) is a major cause of blood-stream infection (BSI) in both healthcare and community settings. While the underlying comorbidities of a patient significantly contributes to their susceptibility to and outcome following SAB, recent studies show the importance of the level of cytolytic toxin production by the infecting bacterium. In this study we demonstrate that this cytotoxicity can be determined directly from the diagnostic MALDI-TOF mass spectrum generated in a routine diagnostic laboratory. With further development this information could be used to guide the management and improve the outcomes for SAB patients.

Source: Microbiology

DOI: 10.1099/mic.0.001223

Authors: Tarcisio Brignoli, Mario Recker, Winnie W. Y. Lee, Tim Dong, Ranjeet Bhamber, Mahableshwar Albur, Philip Williams, Andrew W. Dowsey, Ruth C. Massey

Institutions: University of Bristol, University of Exeter, University of Tübingen, North Bristol NHS Trust, University Hospitals Bristol and Weston NHS Foundation Trust, University College Cork, APC Microbiome Institute

Language: English

Topic: Bacterial Identification and Susceptibility Testing

Subfield: Clinical Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Wellcome Trust, UK Research and Innovation, Department of Health and Social Care, Medical Research Council, Health Data Research UK

Awards: Defining the factors that determine patient outcome following Staphylococcus aureus bacteraemia., G6337683660, G681206065, Improving empiric antibiotic prescribing by applying a Bayesian decision theory approach to phenotypic and genomic resistance data.

OpenAlex ID: W4292723273

FWCI: 0.377

Cites: 23

Cited by: 4

Related to: 10