Year: 2022
Type: article
Abstract: In population studies, dietary patterns clearly influence the development, progression, and therapeutic response of cancers. Nonetheless, interventional dietary trials have had relatively little impact on the prevention and treatment of malignant disease. Standardization of nutritional interventions combined with high-level mode-of-action studies holds the promise of identifying specific entities and pathways endowed with antineoplastic properties. Here, we critically review the effects of caloric restriction and more specific interventions on macro- and micronutrients in preclinical models as well as in clinical studies. We place special emphasis on the prospect of using defined nutrition-relevant molecules to enhance the efficacy of established anticancer treatments. SIGNIFICANCE: The avoidance of intrinsically hypercaloric and toxic diets contributes to the prevention and cure of cancer. In addition, specific diet-induced molecules such as ketone bodies and micronutrients, including specific vitamins, have drug-like effects that are clearly demonstrable in preclinical models, mostly in the context of immunotherapies. Multiple trials are underway to determine the clinical utility of such molecules.
Source: Cancer Discovery
Institutions: Inserm, Institut Universitaire de France, Université Paris Cité, Université Paris-Saclay, Institut Gustave Roussy, Sorbonne Université, Centre de Recherche des Cordeliers, National Institute on Aging, La Ligue Contre le Cancer, Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges-Pompidou
Language: English
Topic: Dietary Effects on Health
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Bristol-Myers Squibb, Sanofi, Association pour la Recherche sur le Cancer, Mark Foundation For Cancer Research, Seerave Foundation, Equipex, European Commission, Agence Nationale de la Recherche, Fondation pour la Recherche Médicale, Ligue Contre le Cancer, Centre National de la Recherche Scientifique, Institut Universitaire de France, Institut National Du Cancer, Institut Gustave-Roussy, PharmaMar, Université de Paris, National Institutes of Health, Labex Immuno-Oncology, National Institute on Aging, Daiichi Sankyo Europe
Awards: G1056382719, Next-generation phenotypic screening for oncological applications, G1956482503, G1963894250, G2786066923, G434337789, G4656594441, G4707887143, G4752891129, G5221946386, Microbiota-centered interventions to solve antibiotics-induced primary resistance to immune checkpoint inhibitors, G7041469554, G7423759087, Université de Paris, Calorie restriction and aging, Aging Intervention Program
OpenAlex ID: W4292731398