Work

Axial Chirality in the Sotorasib Drug Substance, Part 2: Leveraging a High-Temperature Thermal Racemization to Recycle the Classical Resolution Waste Stream

Year: 2022

Type: article

Source: Organic Process Research & Development

DOI: 10.1021/acs.oprd.2c00177

Authors: Matthew G. Beaver, Derek B. Brown, Kiersten Campbell, Yuan-Qing Fang, David D. Ford, Narbe Mardirossian, Kevin D. Nagy, Andreas R. Rötheli, Jillian W. Sheeran, Reem Telmesani, Andrew T. Parsons

Institution: Amgen (United States)

Language: English

Topic: Axial and Atropisomeric Chirality Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: closed

Funder: Amgen

OpenAlex ID: W4292808920

FWCI: 1.81

Cites: 12

Cited by: 26

Related to: 10