Work

Axial Chirality in the Sotorasib Drug Substance, Part 1: Development of a Classical Resolution to Prepare an Atropisomerically Pure Sotorasib Intermediate

Year: 2022

Type: article

Source: Organic Process Research & Development

DOI: 10.1021/acs.oprd.2c00176

Authors: Andrew T. Parsons, Seb Caille, Marc A. Caporini, Daniel J. Griffin, Michael A. Lovette, William Powazinik, Gabrielle St-Pierre

Institution: Amgen (United States)

Language: English

Topic: Axial and Atropisomeric Chirality Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: closed

OpenAlex ID: W4292809578

FWCI: 1.81

Cites: 17

Cited by: 28

Related to: 10