Work

Skin proteomic analysis of immune activation associated with regression of melanoma metastases induced by diphencyprone

Year: 2022

Type: article

Abstract: To the Editor: Diphencyprone (DPCP), a hapten that causes delayed-type hypersensitivity reactions, has been used to treat warts, alopecia areata, and cutaneous metastases in melanoma patients.1 Previously, our group performed transcriptomic analysis of skin biopsies from melanoma metastases treated with topical DPCP, revealing significant increases in Th1-related genes but not in genes of other major T-cell subsets.2 While gene expression profiling has long been used as a proxy for protein expression, correlation between messenger RNA (mRNA) and protein levels is inconsistent due to factors such as post-transcriptional regulation.

Source: JAAD International

DOI: 10.1016/j.jdin.2022.08.006