Year: 2022
Type: article
Abstract: In the course of its short history, mitochondrial DNA (mtDNA) has made a long journey from obscurity to the forefront of research on major biological processes. mtDNA alterations have been found in all major disease groups, and their significance remains the subject of intense research. Despite remarkable progress, our understanding of the major aspects of mtDNA biology, such as its replication, damage, repair, transcription, maintenance, etc., is frustratingly limited. The path to better understanding mtDNA and its role in cells, however, remains torturous and not without errors, which sometimes leave a long trail of controversy behind them. This review aims to provide a brief summary of our current knowledge of mtDNA and highlight some of the controversies that require attention from the mitochondrial research community.
Source: DNA
DOI: 10.3390/dna2020010
Authors: Inna Shokolenko, Mikhail Alexeyev
Institution: University of South Alabama
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,047
Awards: TOWARDS HUMANIZED MOUSE MODELS OF MITOCHONDRIAL DISEASE, Lung endothelial cell phenotypes, G1972305856, Seahorse XFe24 Extracellular Flux Analyzer, G2635671983, DEFINING THE MOLECULAR COMPOSITION OF THE INTERSPECIES BARRIER FOR MITOCHONDRIAL DNA REPLICATION, G4189711061, G6520888366, Mouse models for mitochondrial disorders caused by mutations in mtDNA, Mouse models for mitochondrial disorders caused by mtDNA mutations, G8390724461, G9000144212
OpenAlex ID: W4293083323