Work

Elastic Nanovaccine Enhances Dendritic Cell‐Mediated Tumor Immunotherapy (Small 32/2022)

Year: 2022

Type: article

Abstract: Elastic Nanovaccines In article number 2201108, Zhaogang Teng, Heng Dong, Yongbin Mou, and co-workers report a soft mesoporous organosilica-based nanovaccine (SMONV) and demonstrate that elastic SMONV evokes robust antitumor immune cascades, including lymphatic drainage, antigen internalization and cross-presentation, and tumor-specific T-cell immune responses. Treg-mediated immunosuppression is inhibited after immunization with SMONV. Furthermore, combined administration of anti-PD-L1 antibodies induces tumor regression. The paper provides insight into nanoparticle elasticity and dendritic cell-mediated immunotherapy.

Source: Small

DOI: 10.1002/smll.202270173

Authors: Qiang Li, Zhaogang Teng, Jun Tao, Wenhui Shi, Guangwen Yang, Yu Zhang, Xiaodan Su, Lin Chen, Weijun Xiu, Lihui Yuwen, Heng Dong, Yongbin Mou

Institutions: Nanjing University, Nanjing University of Posts and Telecommunications, The Synergetic Innovation Center for Advanced Materials

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4293120750

FWCI: 0.229

Cites:

Cited by: 3

Related to: 10