Work

Author response: Biphasic regulation of osteoblast development via the ERK MAPK–mTOR pathway

Year: 2022

Type: peer-review

Abstract: Genetic and biochemical analyses uncover a dichotomy of ERK pathway functions in osteoblasts, whereby ERK activation promotes the early differentiation of osteoblast precursors, but inhibits the subsequent differentiation of committed osteoblasts via mTOR-mediated regulation of mitochondrial function and SGK1.

DOI: 10.7554/elife.78069.sa2

Authors: Jung-Min Kim, Yeon-Suk Yang, Jaehyoung Hong, Sachin Chaugule, Hyonho Chun, Marjolein CH van der Meulen, Ren Xu, Matthew B Greenblatt, Jae-hyuck Shim

Institutions: University of Massachusetts Chan Medical School, Korea Advanced Institute of Science and Technology, Hospital for Special Surgery, Cornell University, Xiamen University, Weill Cornell Medicine

Language: English

Topic: Bone Metabolism and Diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4293181645

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