Year: 2022
Type: review
Abstract: How nucleic acids interact with proteins, and how they affect protein folding, aggregation, and misfolding is a still-evolving area of research. Considerable effort is now focusing on a particular structure of RNA and DNA, G-quadruplexes, and their role in protein homeostasis and disease. In this state-of-the-art review, we track recent reports on how G-quadruplexes influence protein aggregation, proteolysis, phase separation, and protein misfolding diseases, and pose currently unanswered questions in the advance of this scientific field.
Source: FEBS Journal
DOI: 10.1111/febs.16608
Authors: Bryan B. Guzman, Ahyun Son, Theodore J. Litberg, Zijue Huang, Daniel Dominguez, Scott Horowitz
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4293194593