Work

Strategies to safely target widely expressed soluble adenylyl cyclase for contraception

Year: 2022

Type: article

Abstract: In humans, the prototypical second messenger cyclic AMP is produced by 10 adenylyl cyclase isoforms, which are divided into two classes. Nine isoforms are G protein coupled transmembrane adenylyl cyclases (tmACs; ADCY1-9) and the 10th is the bicarbonate regulated soluble adenylyl cyclase (sAC; ADCY10). This review details why sAC is uniquely druggable and outlines ways to target sAC for novel forms of male and female contraception.

Source: Frontiers in Pharmacology

DOI: 10.3389/fphar.2022.953903

Authors: Jacob Ferreira, Lonny R. Levin, Jochen Buck

Institution: Weill Cornell Medicine

Language: English

Topic: Phosphodiesterase function and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950