Work

Editor's evaluation: TUBA1A tubulinopathy mutants disrupt neuron morphogenesis and override XMAP215/Stu2 regulation of microtubule dynamics

Year: 2022

Type: peer-review

Abstract: The mechanistic origins of distinct brain malformations associated with different substitutions at α-tubulin residue 409 are examined, revealing disruption of neuronal migration and microtubule regulation by XMAP215 that scales from protein to tissue.

DOI: 10.7554/elife.76189.sa0

Author: Kassandra M Ori-McKenney

Institution: University of California, Davis

Language: English

Topic: Microtubule and mitosis dynamics

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4293226500

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