The Association between Prenatal Nicotine Exposure and Offspring's Hearing Impairment
Year: 2022
Type: article
Abstract: Objectives The objective of this study is to evaluate whether there is an association between in-utero exposure to nicotine and subsequent hearing dysfunction. Materials and Methods Secondary analysis of a multicenter randomized trial to prevent congenital cytomegalovirus (CMV) infection among gravidas with primary CMV infection was conducted. Monthly intravenous immunoglobulin hyperimmune globulin therapy did not influence the rate of congenital CMV. Dyads with missing urine, fetal or neonatal demise, infants diagnosed with a major congenital anomaly, congenital CMV infection, or with evidence of middle ear dysfunction were excluded. The primary outcome was neonatal hearing impairment in one or more ears defined as abnormal distortion product otoacoustic emissions (DPOAEs; 1 to 8 kHz) that were measured within 42 days of birth. DPOAEs were interpreted using optimized frequency-specific level criteria. Cotinine was measured via enzyme-linked immunosorbent assay kits in maternal urine collected at enrollment and in the third trimester (mean gestational age 16.0 and 36.7 weeks, respectively). Blinded personnel ran samples in duplicates. Maternal urine cotinine >5 ng/mL at either time point was defined as in-utero exposure to nicotine. Multivariable logistic regression included variables associated with the primary outcome and with the exposure (p < 0.05) in univariate analysis. Results Of 399 enrolled patients in the original trial, 150 were included in this analysis, of whom 46 (31%) were exposed to nicotine. The primary outcome occurred in 18 (12%) newborns and was higher in nicotine-exposed infants compared with those nonexposed (15.2 vs. 10.6%, odds ratio [OR] 1.52, 95% confidence interval [CI] 0.55–4.20), but the difference was not significantly different (adjusted odds ratio [aOR] = 1.0, 95% CI 0.30–3.31). This association was similar when exposure was stratified as heavy (>100 ng/mL, aOR 0.72, 95% CI 0.15–3.51) or mild (5–100 ng/mL, aOR 1.28, 95% CI 0.33–4.95). There was no association between nicotine exposure and frequency-specific DPOAE amplitude. Conclusion In a cohort of parturients with primary CMV infection, nicotine exposure was not associated with offspring hearing dysfunction assessed with DPOAEs. Key Points
Source: American Journal of Perinatology
Authors: Erin M. Cleary, Douglas A. Kniss, Lida M. Fette, Brenna L. Hughes, George R. Saade, Mara J. Dinsmoor, Uma M. Reddy, Cynthia Gyamfi-Bannerman, Michael W. Varner, William H. Goodnight, Alan T. N. Tita, Geeta K. Swamy, Kent D. Heyborne, Edward K. Chien, Suneet P. Chauhan, Yasser Y. El-Sayed, Brian M. Casey, Samuel Parry, Hyagriv N. Simhan, Peter G. Napolitano, for the Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units (MFMU) Network
Institutions: The Ohio State University, George Washington University, Brown University, The University of Texas Medical Branch at Galveston, Northwestern University, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Columbia University, University of Utah, University of North Carolina at Chapel Hill, University of Alabama at Birmingham, Duke University, University of Colorado Anschutz, Case Western Reserve University, Memorial Hermann, The University of Texas Health Science Center at Houston, Stanford University, The University of Texas Southwestern Medical Center, University of Pennsylvania, University of Pittsburgh, Madigan Army Medical Center
Language: English
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: G1133076894, G124993864, G1641658650, G1915366117, G1977475190, Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network, G2078195037, G242550, G2454580142, NICHD Maternal Fetal Medicine Units Network, G265911422, G2946901798, G3053705670, G3075489137, G3226513114, G3409724790, Cooperative Multicenter Maternal Fetal Medicine Units Networks, G3775748390, G3910300655, Maternal Fetal Units Network: Stanford University and Santa Clara Valley, G444025864, G4640344014, G4821171242, G4908100860, G6209407870, G6223460132, G6300134082, Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network (U10), G670772918, G7191692224, Clinical and Translational Science Award, G8083132335, G8675988754, NICHD Maternal-Fetal Medicine Units (MFMU) Network: Data CoordinatingCenter, Maternal Fetal Medicine Units Network - Northwestern Study Center
OpenAlex ID: W4293237292