Work

Acute kidney injury-associated delirium: a review of clinical and pathophysiological mechanisms

Year: 2022

Type: article

Abstract: Acute kidney injury is a known clinical risk factor for delirium, an acute cognitive dysfunction that is commonly encountered in the critically ill population. In this comprehensive review of clinical and basic research studies, we detail the epidemiology, clinical implications, pathogenesis, and management strategies of patients with acute kidney injury-associated delirium. Specifically addressed are the pathological roles of endogenous toxin or drug accumulation, acute kidney injury-mediated neuroinflammation, and acute kidney injury-associated volume overload as discrete potential biological mechanisms of the condition. The optimization of clinical contributors and normalization of renal function are reviewed as pragmatic management strategies in addition to potential and emerging therapeutic approaches.

Source: Critical Care

DOI: 10.1186/s13054-022-04131-9

Authors: Haoming Pang, Sanjeev Kumar, E. Wesley Ely, Michael M. Gezalian, Shouri Lahiri

Institutions: Cedars-Sinai Medical Center, Vanderbilt University

Language: English

Topic: Intensive Care Unit Cognitive Disorders

Subfield: Critical Care and Intensive Care Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,690