Work

In Vivo Detection of Cyclic-di-AMP in Staphylococcus aureus

Year: 2022

Type: article

Abstract: ABSTRACT Cyclic-di-AMP (CDA) is a signaling molecule that controls various cellular functions including antibiotic tolerance and osmoregulation in Staphylococcus aureus . In this study, we developed a novel biosensor ( bsuO P6-4) for in-vivo detection of CDA in S. aureus . Our study showed that bsuO P6-4 could detect a wide concentration range of CDA in both laboratory and clinical strains making it suitable for use in both basic and clinical research applications.

Source: ACS Omega

DOI: 10.1021/acsomega.2c04538

Authors: Nagaraja Mukkayyan, Raymond Poon, Philipp N. Sander, Li-Yin Lai, Zahra Zubair-Nizami, Ming C. Hammond, Som S. Chatterjee

Institutions: University of Maryland, Baltimore, Institute of Marine and Environmental Technology, University of California, Berkeley, University of Utah, University of Maryland Center for Environmental Science

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,250

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases

Awards: G239389561, G4908177536, G5053316376, Novel Mechanisms of Beta-lactam Resistance in Staph Aureus, G9000012003, G9000165430, G9000256049

OpenAlex ID: W4293373110

FWCI: 0.643

Cites: 30

Cited by: 8

Related to: 10