Work

Long non-coding RNA RGMB-AS1 as a novel modulator of Bone Morphogenetic Protein Receptor 2 signaling in pulmonary arterial hypertension

Year: 2022

Type: preprint

Abstract: This study shows that the long non-coding RNA RGMB-AS1 is upregulated in the blood and pulmonary vascular cells of PAH patient and that it regulates BMPR2 signaling. Inhibiting RGMB-AS1 increases BMPR2 signaling and improves pulmonary vascular cell function.

Source: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.1101/2022.08.27.505495

Authors: Md Khadem Ali, Yu Liu, Lan Zhao, Joseph C. Wu, Vinicio de Jesus Perez, Christopher J. Rhodes, Aiqin Cao, Martin R. Wilkins, Mark R. Nicolls, Edda F. Spiekerkoetter

Institutions: Stanford Medicine, Stanford University, Stanford Cardiovascular Institute, Imperial College London

Language: English

Topic: Pulmonary Hypertension Research and Treatments

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Defense, National Institutes of Health, National Heart, Lung, and Blood Institute

Awards: Targeting Novel BMPR2 modifiers in Pulmonary Hypertension with Repurposed Drugs, G5193776506, G8763608174

OpenAlex ID: W4293507877

Cites: 15

Cited by: 1

Related to: 10