Selective adipocyte loss of Angiopoietin-2 prompts female-specific obesity and metabolic syndrome
Year: 2022
Type: article
Abstract: Thermogenic fat differentiation and function can be promoted through multiple pathways, resulting in a common cell phenotype characterized by the expression of Uncoupling Protein-1 and the ability to dissipate energy, but local and systemic stimuli are necessary to promote adequate thermogenic fat vascularization, which is a precondition for the transport of substrate and the dissipation of heat. Angiopoietin-2 is an important driver of vascularization, and its transcription is in part promoted by estrogen signaling. In this study we demonstrate that adipose tissue-specific knock out of Angiopoietin-2 causes a female-specific reduced thermogenic fat differentiation and function, resulting in obesity and impaired glucose tolerance with end-organ features consistent with metabolic syndrome. In humans, angiopoietin-2 levels are higher in females than in males, and are inversely correlated with adiposity and age more strongly in pre-menopause when compared to post-menopause. Collectively, these data indicate a novel and important role for estrogen-mediated Angiopoietin-2 adipose tissue production in the protection against calorie overload in females, and potentially in the development of postmenopausal weight gain.
Source: Molecular Metabolism
Institutions: Virginia Commonwealth University, Hunter Holmes McGuire VA Medical Center, Virginia Commonwealth University Medical Center, University of Maryland, Baltimore, Inova Health System, University of Chicago, German Center for Lung Research, Charité – Universitätsmedizin Berlin, Baltimore VA Medical Center
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,360
Awards: G1526280338, G1574657605, Longevity Genes in Founder Populations, G443779809, G4868216147, G5376334116, PROVID - Klinische, molekulare und funktionelle Biomarker für Prognose, Pathomechanismen und Behandlungsstrategien von COVID-19 - Teilvorhaben Charité, G569136689, G5791815451, Genome-wide Search for CVD Gene-Environment Interactions, Pharmacogenomics of CVD risk Reduction, SYMPATH - Systemmedizin der Pneumonie-aggravierten Atherosklerose: Klinik und Tiermodelle, Nationales Forschungsnetzwerk der Universitätsmedizin zu Covid-19, University of Maryland Claude D. Pepper Older Americans Independence Center (OAIC), Managing Cardiac Toxicities of Cancer Therapy, CAPSyS - Systemmedizin der ambulant erworbenen Pneumonie - Systemische Inflammation- Erstellung eines umfassenden Krankheitsmodells zur Entwicklung innovativer Diagnostika und Interventionsstrategien
OpenAlex ID: W4293581731