Blunted rest-activity circadian rhythm increases the risk of all-cause, cardiovascular disease and cancer mortality in US adults: the NHANES 2011-2014 linked mortality study
Year: 2022
Type: preprint
Study design: Observational Study
Abstract: Background: Abnormality in rest-activity rhythm is now considered as a manifestation of long-term mild disruption of circadian rhythm in the daily real-world setting. However, whether blunted rest-activity circadian rhythm is associated with increased mortality risk in the general U.S. has not been assessed. Therefore, we aimed to examine whether rest-activity circadian rhythm parameters can predict all-cause, cardiovascular disease (CVD) and cancer mortality in a general adult population of the US. We further compared the mortality predictive performance of these parameters with that of traditional risk factors.Methods: This study included 7,252 adults from US National Health and Nutrition Examination Surveys (NHANES) 2011-2014, who had wrist accelerometer data obtained at baseline and follow-up status linked to the National Death Index records (2011-2019). Cox proportional hazards regression models were performed to estimate Hazard Ratios (HR) and 95% CIs, adjusted for sociodemographic factors, health status and sleep parameters obtained from the same set of accelerometer data. Predictive performance was assessed using 10-fold cross-validated concordance for Cox regression models.Results: Among the 7252 individuals (3826 female (53.4%); median [IQR] age, 49 [36-62] years) in the study, during a median of 81 months (interquartile range, 69-94 months) of follow-up, 674 (9.3%) deaths occurred. There were inverse associations between RA and all-cause mortality, CVD and cancer mortality with increased quartiles of RA associated with lower mortality risk (all P<0.05). The HR ranged from 0.61 to 0.79. Furthermore, RA outperformed all the tested traditional predictors of all-cause mortality with the exception of age.Conclusions: This study suggests that participants with blunted rest-activity circadian rhythms had a higher risk of all-cause, CVD and cancer mortality. Future studies will be needed to test whether interventions that regulate rest-activity circadian activity rhythms will improve health outcomes.
Source: Research Square
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4293582023