Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort
Year: 2022
Type: article
Study design: Observational Study
Abstract: Background: Mycotoxins have been suggested to contribute to a spectrum of adverse health effects in humans, including at low concentrations. The recognition of these food contaminants being carcinogenic, as co-occurring rather than as singularly present, has emerged from recent research. The aim of this study was to assess the potential associations of single and multiple mycotoxin exposures with renal cell carcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Food questionnaire data from the EPIC cohort were matched to mycotoxin food occurrence data compiled by the European Food Safety Authority (EFSA) from European Member States to assess long-term dietary mycotoxin exposures, and to associate these with the risk of renal cell carcinoma (RCC, n = 911 cases) in 450,112 EPIC participants. Potential confounding factors were taken into account. Analyses were conducted using Cox’s proportional hazards regression models to compute hazard ratios (HRs) and 95% confidence intervals (95% CIs) with mycotoxin exposures expressed as µg/kg body weight/day. Results: Demographic characteristics differed between the RCC cases and non-cases for body mass index, age, alcohol intake at recruitment, and other dietary factors. In addition, the mycotoxin exposure distributions showed that a large proportion of the EPIC population was exposed to some of the main mycotoxins present in European foods such as deoxynivalenol (DON) and derivatives, fumonisins, Fusarium toxins, Alternaria toxins, and total mycotoxins. Nevertheless, no statistically significant associations were observed between the studied mycotoxins and mycotoxin groups, and the risk of RCC development. Conclusions: These results show an absence of statistically significant associations between long-term dietary mycotoxin exposures and RCC risk. However, these results need to be validated in other cohorts and preferably using repeated dietary exposure measurements. In addition, more occurrence data of, e.g., citrinin and fumonisins in different food commodities and countries in the EFSA database are a prerequisite to establish a greater degree of certainty.
Source: Nutrients
DOI: 10.3390/nu14173581
Authors: Liesel Claeys, Sarah De Saeger, Ghislaine Scelo, Carine Biessy, Corinne Casagrande, Genevieve Nicolas, Michael Korenjak, Beatrice Fervers, Alicia K. Heath, Vittorio Krogh, Leila Luján-Barroso, Jesús Castilla, Börje Ljungberg, Miguel Rodriguez-Barranco, Ulrika Ericson, Carmen Santiuste, Alberto Catalano, Kim Overvad, Magritt Brustad, Marc J. Gunter, Jiri Zavadil, Marthe De Boevre, Inge Huybrechts
Institutions: Ghent University, World Health Organization, Cancer Research Institute Ghent, Centre international de recherche sur le cancer, University of Johannesburg, Inserm, Centre Léon Bérard, Imperial College London, Fondazione IRCCS Istituto Nazionale dei Tumori, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Umeå University, Instituto de Investigación Biosanitaria de Granada, Andalusian School of Public Health, Lund University, Instituto Murciano de Investigación Biosanitaria, University of Turin, Aarhus University, UiT The Arctic University of Norway
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,722
Funders: Cancer Research Institute, World Health Organization, Kræftens Bekæmpelse, Deutsches Krebsforschungszentrum, Centre International de Recherche sur le Cancer, Cancer Research UK, National Institute for Health and Care Research, Imperial College London, Institut National de la Santé et de la Recherche Médicale, Bundesministerium für Bildung und Forschung, Cancerfonden, Fonds Wetenschappelijk Onderzoek, Ligue Contre le Cancer, Vetenskapsrådet, Fondation de France, Associazione Italiana per la Ricerca sul Cancro, Deutsche Krebshilfe, Institut Gustave-Roussy, Mutuelle Générale de l'Education Nationale, Vlaamse regering, Cocoa Research Institute of Ghana, Medical Research Council, World Cancer Research Fund, European Research Council, Instituto de Salud Carlos III, Rijksinstituut voor Volksgezondheid en Milieu, School of Public Health, Imperial College London
Awards: G1055973116, G1192877484, G1229660973, G1265254713, G1313149160, G1415096210, G1478484880, G1767199718, G1774521243, G1908140502, G1993546569, G2027148636, G2131326840, G2235605558, G2314848362, G2372467518, G2409987178, G2539064604, G2548220501, G2572521044, G2742323354, G29072894, G2933204024, G3077395769, G3084320185, G3178570721, G3189789075, G3216658785, G3328679326, G3544161537, G3592720796, G3747421453, G375319704, G382879149, G4079049029, G4089957676, G412052325, G4187108342, G4213141252, G4303038735, G4370144700, G4421079832, Health of vegetarians, G459595259, G4653965301, G4743021726, G4752739612, G4844208673, G4879533352, G4884057766, G490534113, G493358262, G4968824801, G5004963360, G5372634200, G558017500, G5783272435, G5851461211, G5897142711, G5990830295, G6022976577, G6085534252, G6366438386, G638944333, G6442500046, G6717609686, G6766485657, G6900880554, G6923329853, Impact of multi-mycotoxin exposure on kidney cancer risk: uniting a large-scale epidemiological design & next-generation sequencing coupled with public cancer genomic data mining, G7426181285, G7447125227, G7597388277, G7646326732, G7677770324, G7750343902, G7772080837, G781068995, G7987655622, G8050896463, G8183578868, G8279237360, G8377080268, G8846336397, G8959392569, G8978728421, G9000040826, G9000332718
OpenAlex ID: W4293716813