Statistical Validation of Risk Alleles in Genetic Addiction Risk Severity (GARS) Test: Early Identification of Risk for Alcohol Use Disorder (AUD) in 74,566 Case–Control Subjects
Year: 2022
Type: article
Abstract: Since 1990, when our laboratory published the association of the DRD2 Taq A1 allele and severe alcoholism in JAMA, there has been an explosion of genetic candidate association studies, including GWAS. To develop an accurate test to help identify those at risk for at least Alcohol Use Disorder (AUD), Blum’s group developed the Genetic Addiction Risk Severity (GARS) test, consisting of ten genes and eleven associated risk alleles. In order to statistically validate the selection of these risk alleles measured by GARS, we applied strict analysis to studies that investigated the association of each polymorphism with AUD or AUD-related conditions published from 1990 until 2021. This analysis calculated the Hardy–Weinberg Equilibrium of each polymorphism in cases and controls. If available, the Pearson’s χ2 test or Fisher’s exact test was applied to comparisons of the gender, genotype, and allele distribution. The statistical analyses found the OR, 95% CI for OR, and a post-risk for 8% estimation of the population’s alcoholism prevalence revealed a significant detection. The OR results showed significance for DRD2, DRD3, DRD4, DAT1, COMT, OPRM1, and 5HTT at 5%. While most of the research related to GARS is derived from our laboratory, we are encouraging more independent research to confirm our findings.
Source: Journal of Personalized Medicine
DOI: 10.3390/jpm12091385
Institutions: Eötvös Loránd University, University of Vermont, Wright State University, Dayton VA Medical Center, Western University of Health Sciences, The University of Texas at San Antonio, Thomas Jefferson University Hospital, Audie L. Murphy Memorial VA Hospital, South Texas Veterans Health Care System, Cambridge Health Alliance, Boston Children's Hospital, Harvard University, Center for Pain and the Brain, University at Buffalo, State University of New York, Texas Southern University, Howard University, Washington University in St. Louis, Ariel University
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,094
Awards: A Systematic Medical Approach to Reward Transformation (SMART) for Brain Health in Opioid Use Disorder, G1486399767, G1959364948, G2376444452, G355412730, Excessive Alcohol Drinking Associated with GABA Alpha 2-Regulated TLR4 Expression, G6556065039, G7562078480, District of Columbia Center for AIDS Research, Howard University Research Center for Minority Health and Health Disparities
OpenAlex ID: W4293758661