Survival of epithelial ovarian cancer in Black women: a society to cell approach in the African American Cancer Epidemiology Study (AACES)
Year: 2022
Type: preprint
Study design: Observational Study
Abstract: Purpose: The five-year relative survival for epithelial ovarian cancer (EOC) is worse among Black women compared with White women. The causes for this disparity are likely multi-factorial but unclear as to date, no cohort study has focused specifically on Black EOC survivors. Here we present the African-American Cancer Epidemiology Study (AACES), the largest cohort of Black women diagnosed with EOC. Methods: Phase 1 began in 2010 as a multi-site population-based case-control study focused on risk, and phase 2 began enrolling newly diagnosed EOC cases in 2020. Phase 2 builds on existing infrastructure with the goal to increase the number of EOC cases by 50% and evaluate factors affecting survival with a society-to-cell approach. Both phases use rapid case ascertainment to identify potential participants and collect extensive survey data, biospecimens, medical record abstraction, and annual follow-up.Results: Phase 1 enrolled 592 women with EOC, with a median survival of 4.8 years as of 2021. These survival rates approximate those of Black women in SEER who survive at least 10 months past diagnosis. A high proportion of the cohort was found to have relatively low levels of household income, education, and insurance coverage. Conclusions and Implications for Cancer Survivors: AACES is well-positioned to evaluate the contribution of social determinants of health to the poor survival of Black women with EOC, advance understanding of the multi-factorial causes of the ovarian cancer survival disparity in Black women, and serve as an example of a multi-site, epidemiologic population-based study of a rare cancer in a minority population.
Source: Research Square
Authors: Joellen M. Schildkraut, Courtney Johnson, Lauren F. Dempsey, Bo Qin, Paul Terry, Maxwell Akonde, Edward S. Peters, Hannah Mandle, Michele L. Cote, Lauren Peres, Patricia Moorman, Ann G. Schwartz, Michael Epstein, Jeffrey Marks, Melissa Bondy, Andrew B. Lawson, Anthony J. Alberg, Elisa V. Bandera
Institutions: Emory University, Rutgers, The State University of New Jersey, University of Tennessee Medical Center, University of South Carolina, University of Nebraska Medical Center, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Moffitt Cancer Center, Duke University, Wayne State University, The Barbara Ann Karmanos Cancer Institute, Stanford Medicine, Stanford University, Medical University of South Carolina
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4293785498