Work

The dual nature of the nucleolus

Year: 2022

Type: preprint

Abstract: The nucleolus is best known for housing the highly ordered assembly line that produces ribosomal subunits. The >100 ribosome assembly factors in the nucleolus are thought to cycle between two states: an operative state (when integrated into subunit assembly intermediates) and a latent state (upon release from intermediates). Although it has become commonplace to refer to the nucleolus as "being a multilayered condensate," and this may be accurate for latent factors, there is little reason to think that such assertions pertain to the operative state of assembly factors.

Source: Genes & Development

DOI: 10.1101/gad.349748.122

Authors: Alan Tartakoff, Patrick DiMario, Eduard Hurt, Brian McStay, Vikram Govind Panse, David Tollervey