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Seeded growth of adaptive tiles on DNA origami

Year: 2022
Type: article
Abstract: Structural DNA nanotechnology has been applied to construct complex static and dynamic DNA structures. Seeded growth, intended to regulate the crucial nucleation step, has been used to control the assembly of DNA tiles. However, most of the seeded growth strategies were applied to fixed DNA tiles, whereas the seeded growth on dynamic DNA tiles remains unreported. Here, we propose a seeded growth strategy in which dynamic tiles adaptively change their shapes to match the architecture of a DNA origami seed. Furthermore, when more adaptive DNA tiles assemble on a reconfigurable DNA origami domino array (DODA) seed, the conformation of DODA seeds is reversibly affected by the spontaneous reconfiguration of adaptive tiles. The adaptive seeded growth provides a mechanism for the construction of complex DNA nanomachines and may offer a general and adaptable method for the advancement of responsive materials, with active, autonomous, and adaptive spatiotemporal control properties.
DOI: 10.1016/j.xcrp.2022.101040
Authors: Yan Liu, Jin Cheng, Yuqi Wang, Bin Ji, Linlin Tang, Kexuan Zou, Yujie Xie, Daxiang Cui, Yonggang Ke, Jie Song
Institutions: Shanghai Jiao Tong University, Shanghai University, Georgia Institute of Technology, Emory University, The Wallace H. Coulter Department of Biomedical Engineering, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Language: English
Open Access status: gold
Estimated APC paid: $5,200
Awards: G1369235006, G2710635761, G4251804288, G4457222860, G6089423532, G724750445, G8038267524, G8086905047, G8608450923
OpenAlex ID: W4294012864
FWCI: 0.082
Cites: 61
Cited by: 1
Related to: 10