Work

Role of the paraventricular nucleus of the hypothalamus in sleep–wake regulation

Year: 2022

Type: article

Abstract: The paraventricular nucleus of the hypothalamus (PVH) acts as a cohesive functional unit that regulates neuroendocrine and autonomic function, complex behavior, and negative emotions after stress. However, how the PVH integrates arousal with these biological functions has only recently been explored. Clinical reports, combined with neurotoxic lesioning, immunochemistry, neuronal activity recordings, and the polysomnographic analyses of genetically modified animals, have revealed that the PVH is important for the control of wakefulness. Here, we review emerging anatomical and neural mechanisms for sleep–wake regulation in the PVH to support its essential role in the promotion and maintenance of wakefulness.

Source: Brain Science Advances

DOI: 10.26599/bsa.2022.9050017

Authors: Shan Jiang, Lu Chen, Zhi-Li Huang, Chang-Rui Chen

Institutions: Shanghai Medical College of Fudan University, Fudan University, State Key Laboratory of Medical Neurobiology, Frontiers Center for Brain Science of the Ministry of Education

Language: English

Topic: Sleep and Wakefulness Research

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4294026056

FWCI: 0.715

Cites: 64

Cited by: 7

Related to: 10